Extend Your Mass Range
High-Mass Analysis and Nanoparticle Detection
Measure single ions, large complexes, and nanoparticles with RF transport, accumulation, electrostatic optics, electrospray control, and integrated detection.
How Researchers Use Our Products
How Researchers Use Ardara
Explore the instrument challenge, the Ardara solution selected, and the performance reported by each research team.
Used by researchers
2017
University of California, Berkeley
Mass, Mobility and MSn Measurements of Single Ions Using Charge Detection Mass Spectrometry
- Solution used
- Two RF-only quadrupole ion guides; energy-selective electrostatic turning quadrupole
The Berkeley charge-detection mass spectrometer incorporated a pair of Ardara RF-only quadrupole guides and an energy-selective electrostatic turning quadrupole. Together, these elements enabled repeated manipulation and measurement of individual highly charged ions. The authors demonstrated MS7 analysis of a single multiply charged, approximately 8 MDa polyethylene glycol ion and reported about one percent energy precision. The work illustrates how Ardara ion optics can support single-particle experiments that require controlled recirculation, selection, and low-loss transport.
Published by Elliott et al. in Analyst (2017).
Used by researchers
2021
University of California, Berkeley
Direct Observation of Ion Emission from Charged Aqueous Nanodrops: Effects on Gaseous Macromolecular Charging
- Solution used
- Two RF quadrupole ion guides; the second guide used for ion accumulation
Two Ardara RF quadrupole guides transported and accumulated charged aqueous nanodrops for charge-detection mass spectrometry; the second guide supported accumulation times up to one second. The study directly observed ion emission from nanodrops 15 to 32 nm in diameter, spanning roughly 1 to 10 MDa and about 50 to 300 elementary charges. This application shows Ardara ion guides operating in a regime far beyond conventional small-molecule analysis, enabling controlled measurements of highly charged nanoscale objects and electrospray charging mechanisms.
Published by Harper et al. in Chemical Science (2021).
Co-developed with Ardara
2023
University of California, Berkeley and Ardara Technologies
Accurate Sizing of Nanoparticles Using a High-Throughput Charge Detection Mass Spectrometer without Energy Selection
- Solution used
- +/-4 kV electrospray supply, Broad-Head RF supplies, thin gate valve, three rectilinear quadrupole guides, and asymptotic electrodes
This high-throughput charge-detection instrument incorporated an unusually broad set of Ardara subsystems spanning ionization, RF transport, gating, and electrostatic optics. Nanoparticle size distributions agreed with transmission electron microscopy while measurements were completed up to roughly 80 times faster, including samples diluted about 50-fold; the instrument also resolved particle dimers. The coauthored paper is a clear public example of Ardara contributing to an integrated platform rather than a single replaceable component.
Published by Harper et al.; Randall E. Pedder was an Ardara-affiliated coauthor in ACS Nano (2023).
Plan Your Instrument with Ardara
Share your pressure regime, target mass range, RF or DC requirements, geometry, and control constraints. Our team can help match catalog components to your design or define a custom subsystem.